Research Interests
Research Experience
2012
Post Doctoral Research at IIITM-K, Thiruvananthapuram in computational Chemistry.
2011
Ph. D., Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
Thesis: “Synthesis and Biological Evaluation of α‐Methylene‐γ‐butyrolactones”
(Supervisor: Prof. P. V. Ramachandran)
– Synthesized a variety of α-methylene-γ-butyrolactones and studied their activity against various cancer cell lines.
– Developed trifluorocrotylboration.
– Developed one-pot asymmetric synthesis of THF derivatives.
2003
M.Sc. Research Project (at IIT, Kanpur, India)
“Regiospecific Synthesis of Substituted Naphthalenes”(Supervisor: Prof. H. I. Ila)
Education
2011. Ph.D.
Purdue University, West Lafayette, Indiana, USA.
GPA: 4.00 (out of 4.00)
Title of the Ph.D. thesis: “Synthesis and Biological Evaluation of α‐Methylene‐γ‐butyrolactones”
2004 M.Sc. in Chemistry with specialization in Organic Chemistry
School of Chemical Sciences,Mahatma Gandhi University, Kottayam, India (First Class with Distinction)
2001 B.Sc. in Chemistry
St. Thomas College, Pala, India (First Class)
2016 Counselling
Certificate Cours in Counselling, Mahatma Gandhi University
Awards and Honors
Best Poster Award, Negishi-Brown Lectures, Purdue University, USA.
2ndrank in M. Sc. Chemistry (Organic Chemistry) from Mahatma Gandhi University, Kottayam, India.
Appointments
Master Trainer for “Mukhamukham” Programme
Master Trainer, MGU-UGP
Member, FYUGP MG University (MGU-UGP) IT Subcommittee
HoD, Department of Chemistry, Devaswom Board College, Thalayolaparambu, 2022
UG Board of Studies Member of Mahatma Gandhi University, 2021
Lieutenant rank in NCC, 2018
ANO of NCC Devaswom Board College, Thalayolaparambu, 2018
Research Guide at Devaswom Board College, Thalayolaparambu 2018
Teaching Experience
Working as assistant professor in Devaswom Board College since 2012.
Worked as teaching assistant for lecture courses and laboratory courses at Purdue University, USA.
Worked as head teaching assistant for lecture courses and laboratory courses at Purdue University, USA
Talks Given
Original Proposal to Synthesize Archazolid A
Purdue University, West Lafayette, Indiana, USA.
Synthesis of Flourinated α-methyl-γ-butyrolactones and their Pancreatic Cancer Activities
Purude University, West Lafayette, Indiana, USA.
Boron in Organic Chemistry
St.Xavier’s College, Vaikom, Kothavara
Glimpses of Brain Chemistry
Chemistry Association,D.B. College, Thalayolaparambu
Chemistry of Love
Science Forum, D.B. College, Thalayolaparambu
Happiness and Addiction
WWS programme, D.B. College, Thalayolaparambu
Brain Chemistry
Auxilium College of Education, Angamaly
…and more.
Publications
1. Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic
carcinoma cells. Ramachandran. P. V.; Pratihar, D.; Nair, H. N. G. et al. Bioorg. Med. Chem.
Lett., 2010, 20, 6620.
2. One-pot asymmetric synthesis of 2- and 2,3-disubstituted tetrahydrofuran derivatives. Ramachandran, P. V.; Nair, H. N. G.; Gagare, P. D. J. Org. Chem. 2012,77, 5394.
3. Synthetic α-aminomethyl-γ-butyrolactones and their anti-pancreatic cancer activities. Ramachandran. P. V.;Nicponski, D.R.; Nair, H. N. G. et al. Bioorg. Med. Chem.Lett., 2013, 23, 6911.
4. Regiospecific Synthesis of Substituted Naphthalene. Hari Narayanan G., Journal of dbct 2014, 1, 29.
5. Syntheses of b– and γ-Fluorophenyl cis- and trans-α-Methylene-γ-Butyrolactones– Ramachandran, P. V.; Nair, H. N. G. et al. Tet. Lett. 2014, 55, 5722.
6. Antidermatophytic and Protease-inhibiting Activities of Zerumbone: A Natural Sesquiterpene from the Rhizome of Zingiber zerumbet (L.) Roscoe ex J.E; Smith. Madhavankutty Jyothilakshmi; Mathew Jyothis; Gokulanathan Nair Hari Narayanan; Mukalel Sankunni Latha; Pharmacogn. Mag. 2017, 13, 2.
